Objective. The aim of this study was to evaluate the association between the Trp64Arg polymorphism in the beta3-adrenergic receptor\r\ngene (ADRB3: rs4994) and BMI and serological and anthropometric data in healthy Japanese. Methods. Healthy Japanese recruited\r\nin a large-scale integrated manufacturing facility in Japan (N = 1355; age: 37.25 �± 9.43; BMI: 22.86 �± 3.46) were eligible for\r\nanalysis. The anthropometric data and serological data were measured during a comprehensive health check, and a self-reporting\r\nquestionnaire was used to assess lifestyle habits (current exercise, smoking status, alcohol intake, and working style) and weight at\r\nage 20. Genotyping for the ADRB3 polymorphism was performed by PCR-RFLP method. Results. Among 1355 participants, the\r\ngenotype frequencies of the Trp/Trp, Trp/Arg, and Arg/Arg variants were 920 (67.9%), 394 (29.1%), and 41 (3.05%), respectively. In\r\nthe multivariate analysis, a multiple linear regression model in men for the adjustment of age, drinking habits, smoking habits,\r\nexercise habits, working status and serological measurements statistically showed an overall weak significance between annual BMI\r\ngain from age 20 and age, LDL or ADRB3 polymorphism. Conclusions. The level of LDL, age, and ADRB3 polymorphism (Arg/Arg\r\ngenotype) were statistically associated with annual BMI gain in Japanese men.
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